Search results for "Activity profile"
showing 4 items of 4 documents
Comparison of the activity profile during Grand Slam women’s doubles tennis
2021
Characteristic ERK Signaling Dynamics Distinguishes Necroptosis from Apoptosis
2021
ERK involvement in cell death remains unclear, although many studies have demonstrated the importance of ERK dynamics in determining cellular responses. To untangle ERK’s contribution in two cell death programs, we investigated ERK signaling dynamics during hFasL-induced apoptosis and TNF-induced necroptosis in L929sAhFas cells. We observed that ERK inhibition sensitizes cells to apoptosis while delaying necroptosis. By monitoring ERK activity by live-cell imaging using an improved ERK biosensor (EKAR4.0), we reported differential ERK signaling dynamics between cell survival, apoptosis, and necroptosis. We also decrypted a temporally shifted amplitude- and frequency-modulated (AM/FM) ERK ac…
Discovery of γ-secretase modulators with a novel activity profile by text-based virtual screening.
2012
We present an integrated approach to identify and optimize a novel class of γ-secretase modulators (GSMs) with a unique pharmacological profile. Our strategy included (i) virtual screening through application of a recently developed protocol (PhAST), (ii) synthetic chemistry to discover structure–activity relationships, and (iii) detailed in vitro pharmacological characterization. GSMs are promising agents for treatment or prevention of Alzheimer’s disease. They modulate the γ-secretase product spectrum (i.e., amyloid-β (Aβ) peptides of different length) and induce a shift from toxic Aβ42 to shorter Aβ species such as Aβ38 with no or minimal effect on the overall rate of γ-secretase cleavag…
Activity profile, PlayerLoad™ and heart rate response of Gaelic football players : A pilot study
2019
The objectives of this study were to; quantify positional differences in the activity profiles of Gaelic football players and to evaluate decrements in physical performance during a pre-season competition. Global positioning system (GPS) data was recorded from 36 players from 3 teams across 5 games. The relative distance covered in locomotor activities, peak speed, relative PlayerLoad™ (PL.min -1 )and heart rate responses were evaluated between playing positions and across match periods using a mixed model analysis. The mean relative distance of 92.4 ± 23.3 m.min -1 covered,comprised 28.4 ± 10.2 m.min -1 of high intensity running (m.min -1 ≥4.0 m.s -1 ) and 9.9 ± 3.9 m.min -1 of very high i…